Brain morphology and response to nortriptyline in geriatric depression

Am J Geriatr Psychiatry. 1999 Spring;7(2):147-50.

Abstract

In geriatric patients with major depression (N=15), the authors compared response to treatment with nortriptyline as it relates to brain morphology assessed by computed tomography. There was a significant negative association between ventricle-brain ratio and response to nortriptyline (rs=-0.63; P=0.015).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Aged
  • Antidepressive Agents, Tricyclic / blood
  • Antidepressive Agents, Tricyclic / pharmacology*
  • Antidepressive Agents, Tricyclic / therapeutic use*
  • Brain / diagnostic imaging*
  • Brain / drug effects*
  • Depressive Disorder, Major / diagnosis
  • Depressive Disorder, Major / drug therapy*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Nortriptyline / blood
  • Nortriptyline / pharmacology*
  • Nortriptyline / therapeutic use*
  • Predictive Value of Tests
  • Prospective Studies
  • Severity of Illness Index
  • Tomography, X-Ray Computed
  • Treatment Outcome

Substances

  • Antidepressive Agents, Tricyclic
  • Nortriptyline