Chemistry and biological activities of constituents from Morus australis

Biochim Biophys Acta. 1999 Aug 5;1428(2-3):293-9. doi: 10.1016/s0304-4165(99)00084-7.

Abstract

A novel constituent named australone B (1) was further isolated from the cortex of Morus australis (Moraceae). The structure of 1 has been elucidated by one- and two-dimension spectra. In human citrated platelet-rich plasma, 1 showed strong inhibition of aggregation induced by adrenaline in a concentration-dependent manner with an IC(50) value of about 33.3 microM. Compound 1 (30 microM) also showed inhibitory effects on superoxide anion formation from rat neutrophils stimulated with formyl-Met-Leu-Phe (fMLP)/cytochalasin B (CB). Morusin (2) inhibited superoxide anion formation from rat neutrophils stimulated with phorbol myristate acetate (PMA) in a concentration-dependent manner with an IC(50) value of 66.9+/-2.5 microM.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Degranulation
  • Cytochalasin B
  • Flavonoids / chemistry*
  • Flavonoids / pharmacology
  • Magnetic Resonance Spectroscopy
  • Mast Cells / drug effects
  • Mast Cells / physiology
  • Molecular Structure
  • N-Formylmethionine Leucyl-Phenylalanine
  • Neutrophils / drug effects
  • Neutrophils / physiology
  • Platelet Aggregation Inhibitors / chemistry*
  • Platelet Aggregation Inhibitors / pharmacology
  • Rats
  • Taiwan
  • Tetradecanoylphorbol Acetate
  • Trees / chemistry*

Substances

  • Flavonoids
  • Platelet Aggregation Inhibitors
  • australone B
  • Cytochalasin B
  • N-Formylmethionine Leucyl-Phenylalanine
  • morusin
  • Tetradecanoylphorbol Acetate