Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models

Antimicrob Agents Chemother. 1999 Oct;43(10):2555-8. doi: 10.1128/AAC.43.10.2555.

Abstract

The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(4-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antimalarials / pharmacology*
  • Artemisinins*
  • Chloroquine / pharmacology
  • Drug Resistance
  • Drug Synergism
  • Erythrocytes / parasitology
  • Humans
  • Metalloporphyrins / pharmacology*
  • Plasmodium falciparum / drug effects*
  • Sesquiterpenes / pharmacology*

Substances

  • Antimalarials
  • Artemisinins
  • Metalloporphyrins
  • Sesquiterpenes
  • Chloroquine
  • artemisinin