Vincristine treatment revealing asymptomatic hereditary motor sensory neuropathy type 1A

Arch Dis Child. 1999 Nov;81(5):442-3. doi: 10.1136/adc.81.5.442.

Abstract

A 5 year old boy developed severe weakness after receiving vincristine for treatment of acute lymphoblastic leukaemia. Although weakness improved after the discontinuation of vincristine, other symptoms suggestive of a neuropathy persisted. Neurophysiological and genetic analysis at age 8 years indicated that vincristine had induced symptoms of a hereditary sensory motor neuropathy type 1A, which had previously been asymptomatic; his genetically affected mother was also asymptomatic.

Publication types

  • Case Reports

MeSH terms

  • Antineoplastic Agents, Phytogenic / adverse effects*
  • Charcot-Marie-Tooth Disease / chemically induced*
  • Charcot-Marie-Tooth Disease / genetics
  • Child, Preschool
  • Follow-Up Studies
  • Humans
  • Male
  • Vincristine / adverse effects*

Substances

  • Antineoplastic Agents, Phytogenic
  • Vincristine