Genetic mapping of complex traits

Stat Med. 1999 Nov 15;18(21):2961-81. doi: 10.1002/(sici)1097-0258(19991115)18:21<2961::aid-sim206>3.0.co;2-u.

Abstract

Statistical genetic mapping methods are powerful tools for finding genes that contribute to complex human traits. Mapping methods combine knowledge of the biological mechanisms of inheritance and the randomness inherent in those mechanisms to locate, with increasing precision, trait genes on the human genome. We provide an overview of the two major classes of mapping methods, genetic linkage analysis and linkage disequilibrium analysis, and related concepts of genetic inheritance.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Chromosome Mapping / methods*
  • Computer Simulation*
  • Female
  • Genetic Markers / genetics
  • Humans
  • Male
  • Models, Genetic*
  • Models, Statistical*
  • Quantitative Trait, Heritable

Substances

  • Genetic Markers