Abstract
The presence and distribution of Epstein-Barr virus (EBV), as well as human herpesvirus-6 and-8 (HHV-6 and HHV-8) was investigated by polymerase chain reaction in 191 samples from a variety of lymphoproliferative disorders. HHV-6 DNA was detected in 18% (30 of 169) of non-HHV-8 related lymphoproliferative disorders, with the highest frequency in AIDS-related lymphomas (8 of 25, 32%). In contrast, HHV-6 DNA was present in less than 5% (1 of 22) of HHV-8 related lymphoproliferative disorders [21 primary effusion lymphomas (PEL), and 1 cases of Castleman disease]. As compared to HHV-6, EBV DNA was frequently detected in PEL (11 of 19 samples, 58%). This study suggests that transformation to PEL is not enhanced by HHV-6, furthermore HHV-6 and -8 may interfere with each other.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Castleman Disease / epidemiology
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Castleman Disease / virology
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Cell Transformation, Neoplastic
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Cell Transformation, Viral
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Comorbidity
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DNA, Viral / isolation & purification
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Epstein-Barr Virus Infections / complications
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Epstein-Barr Virus Infections / epidemiology
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Herpesviridae Infections / complications
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Herpesviridae Infections / epidemiology*
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Herpesvirus 4, Human / isolation & purification
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Herpesvirus 4, Human / pathogenicity
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Herpesvirus 6, Human / isolation & purification*
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Herpesvirus 6, Human / pathogenicity
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Herpesvirus 8, Human / isolation & purification*
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Herpesvirus 8, Human / pathogenicity
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Humans
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Japan / epidemiology
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Lymphoma, AIDS-Related / epidemiology
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Lymphoma, AIDS-Related / virology
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Lymphoma, B-Cell / epidemiology
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Lymphoma, B-Cell / virology*
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Lymphoma, B-Cell, Marginal Zone / epidemiology
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Lymphoma, B-Cell, Marginal Zone / virology
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Lymphoma, Non-Hodgkin / epidemiology
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Lymphoma, Non-Hodgkin / virology
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Lymphoproliferative Disorders / epidemiology
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Lymphoproliferative Disorders / virology
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Polymerase Chain Reaction
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Prevalence
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Tumor Virus Infections / complications
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Tumor Virus Infections / epidemiology*
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Viral Interference