Notch signaling is not sufficient to define the affinity boundary between dorsal and ventral compartments

Mol Cell. 1999 Dec;4(6):1073-8. doi: 10.1016/s1097-2765(00)80235-x.

Abstract

The developing limbs of Drosophila are subdivided into distinct cells populations known as compartments. Short-range interaction between cells in adjacent compartments induces expression of signaling molecules at the compartment boundaries. In addition to serving as the sources of long-range signals, compartment boundaries prevent mixing of the adjacent cell populations. One model for boundary formation proposes that affinity differences between compartments are defined autonomously as one aspect of compartment-specific cell identity. An alternative is that the affinity boundary depends on signaling between compartments. Here, we present evidence that the dorsal selector gene apterous plays a role in establishing the dorsoventral affinity boundary that is independent of Notch-mediated signaling between dorsal and ventral cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Drosophila / embryology*
  • Drosophila Proteins
  • Embryo, Nonmammalian / physiology*
  • Extremities / embryology
  • Membrane Proteins / physiology*
  • Receptors, Cell Surface / physiology
  • Receptors, Notch
  • Signal Transduction

Substances

  • Drosophila Proteins
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Cell Surface
  • Receptors, Notch