Abstract
Here, we review the WNT pathway and its regulation at different levels. We focus on the transcriptional regulation of WNT target genes, in light of the recently identified negative regulators, i.e. relatives of groucho and CBP.
MeSH terms
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Animals
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Cytoskeletal Proteins / metabolism
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DNA-Binding Proteins / physiology
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Embryo, Nonmammalian
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Gene Expression Regulation, Developmental*
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Lymphoid Enhancer-Binding Factor 1
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins / physiology*
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Trans-Activators*
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Transcription Factors / physiology
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Wnt Proteins
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Xenopus
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Xenopus Proteins
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Zebrafish Proteins*
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beta Catenin
Substances
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CTNNB1 protein, Xenopus
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Cytoskeletal Proteins
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DNA-Binding Proteins
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Lymphoid Enhancer-Binding Factor 1
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Proto-Oncogene Proteins
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Trans-Activators
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Transcription Factors
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Wnt Proteins
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Xenopus Proteins
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Zebrafish Proteins
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beta Catenin