[Substituted cyclodextrins as chelating reagents for ethers, thioethers and yperite]

Ann Pharm Fr. 2000 Jan;58(1):20-3.
[Article in French]

Abstract

The complexation of mustard gas Cl(CH(2))(2)S(CH(2))(2) Cl, HD, yperite) and of ethers and thioethers derivatives by cyclodextrins: natural alpha-cyclodextrin (ACD) and substituted B-cyclodextrins was studied by NMR. A 1/1 stoechiometry was found in all cases, while affinity constants were found relatively weak (from 5 M(-1) to 100 M(-1)). However, these results show that chelation of HD by cyclodextrins can be reasonably expected, especially if chemical modifications provide stronger affinity constants.

Publication types

  • English Abstract

MeSH terms

  • Antidotes / chemistry*
  • Carbohydrate Sequence
  • Chelating Agents / chemistry*
  • Cyclodextrins / chemistry*
  • Ethers / chemistry*
  • Molecular Sequence Data
  • Mustard Gas / chemistry*
  • Nuclear Magnetic Resonance, Biomolecular
  • Sulfides / chemistry*

Substances

  • Antidotes
  • Chelating Agents
  • Cyclodextrins
  • Ethers
  • Sulfides
  • Mustard Gas