Visual hallucinations in recovery from cortical blindness: imaging correlates

Arch Neurol. 2000 Apr;57(4):561-5. doi: 10.1001/archneur.57.4.561.

Abstract

Objective: To investigate the cerebral metabolic and functional patterns during recovery from cortical blindness.

Design: Follow-up study with serial clinical, metabolic, and functional imaging and visual evoked potentials.

Case presentation: A 24-year-old woman suffered from cortical blindness after cardiac arrest and recovered over a 6-month period. During recovery, she experienced complex visual hallucinations that could be initiated by visual imagery.

Results: Initially, the regional cerebral metabolic rate of glucose was severely reduced in the visual and parieto-occipital cortex bilaterally but recovered almost completely. Visual hallucinations led to significant increases of the regional cerebral blood flow in the initially severely hypometabolic parieto-occipital and temporo-lateral cortex.

Conclusions: Recovery of vision was related to normalization of the postlesionally dysfunctional cortex. Visual hallucinations appeared as the clinical correlate of the electrophysiological hyperexcitability of the recovering partially damaged visual cortex.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Blindness, Cortical / diagnostic imaging
  • Blindness, Cortical / etiology*
  • Blindness, Cortical / physiopathology
  • Cardiopulmonary Resuscitation
  • Cerebral Cortex / blood supply
  • Cerebral Cortex / diagnostic imaging
  • Cerebrovascular Circulation / physiology
  • Evoked Potentials, Visual / physiology
  • Female
  • Fluorodeoxyglucose F18
  • Follow-Up Studies
  • Hallucinations / etiology*
  • Heart Arrest / complications*
  • Humans
  • Recovery of Function*
  • Tomography, Emission-Computed
  • Visual Cortex / blood supply
  • Visual Cortex / diagnostic imaging
  • Visual Cortex / physiopathology

Substances

  • Fluorodeoxyglucose F18