Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor

A J Phillips; Y Uto; P Wipf; M J Reno; D R Williams

doi:10.1021/ol005777b

Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor

Org Lett. 2000 Apr 20;2(8):1165-8. doi: 10.1021/ol005777b.

Authors

A J Phillips¹, Y Uto, P Wipf, M J Reno, D R Williams

Affiliation

¹ Department of Chemistry, University of Pittsburgh, Pennsylvania 15260, USA.

PMID: 10804580
DOI: 10.1021/ol005777b

Abstract

[formula: see text] A mild and highly efficient cyclization of beta-hydroxy amides to oxazolines is described using DAST and Deoxo-Fluor reagents. A one-pot protocol for the synthesis of oxazoles from beta-hydroxy amides is also presented.

Publication types

Research Support, U.S. Gov't, P.H.S.

MeSH terms

Diethylamines / chemistry*
Fluorine / chemistry*
Indicators and Reagents / chemistry*
Oxazoles / chemical synthesis*

Substances

Diethylamines
Indicators and Reagents
Oxazoles
Fluorine
diethylaminosulfur trifluoride

Abstract

Publication types

MeSH terms

Substances

Grants and funding