Synthesis of functionalized oxazolines and oxazoles with DAST and Deoxo-Fluor

Org Lett. 2000 Apr 20;2(8):1165-8. doi: 10.1021/ol005777b.

Abstract

[formula: see text] A mild and highly efficient cyclization of beta-hydroxy amides to oxazolines is described using DAST and Deoxo-Fluor reagents. A one-pot protocol for the synthesis of oxazoles from beta-hydroxy amides is also presented.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Diethylamines / chemistry*
  • Fluorine / chemistry*
  • Indicators and Reagents / chemistry*
  • Oxazoles / chemical synthesis*

Substances

  • Diethylamines
  • Indicators and Reagents
  • Oxazoles
  • Fluorine
  • diethylaminosulfur trifluoride