[Genetic heterogeneity of non-specific mental retardation]

J Chen; Y Guo; M Zhao

[Genetic heterogeneity of non-specific mental retardation]

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2000 Jun;17(3):185-7.

[Article in Chinese]

Authors

J Chen¹, Y Guo, M Zhao

Affiliation

¹ Department of Medical Genetics, Shandong Medical University, Jinan, Shandong, 250012 P. R. China. chenjie81@163.net

PMID: 10837521

Abstract

Objective: To explore genetic patterns of non-specific mental retardation (NSMR).

Methods: Using segregation analysis, Finney method and Falconer method, the authors studied 157 pedigrees with NSMR selected in a population survey in Shandong province.

Results: Ux U multiplex families may accept the autosomal recessive inheritance, Ux U total families is the autosomal recessive inheritance while it may be the multifactorial inheritance with major-gene effect, the frequency of sporadic cases is approximately 46%; Ux A mating families may keep the incomplete penetrance in autosomal dominant inheritance.

Conclusion: The genetic pattern of NSMR has the genetic heterogeneity.

Publication types

English Abstract
Research Support, Non-U.S. Gov't

MeSH terms

Female
Genetic Variation*
Humans
Intellectual Disability / genetics*
Male