Abstract
Five dihydrobenzofuran neolignans, woorenosides I (1), II (2), III (3), IV (4), and V (5), isolated from Coptis japonica (Ranunculaceae), suppressed tumor necrosis factor (TNF)-alpha and nitric oxide (NuOmicron) production, as well as lymphocyte proliferation triggered by inflammatory signals such as various mitogens, in a dose-dependent manner. The results indicate that the woorenosides strongly inhibit the mitogenic response by activated macrophage and lymphocytes and suggest that these compounds may participate in regulating inflammatory processes.
MeSH terms
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / isolation & purification
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Cell Line
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Interleukin-2 / pharmacology
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Lignans / isolation & purification
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Lignans / pharmacology*
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Lymphocytes / drug effects
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Lymphocytes / metabolism
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Macrophages / drug effects
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Macrophages / metabolism
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Male
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Mice
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Mice, Inbred BALB C
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Nitric Oxide / antagonists & inhibitors
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Nitric Oxide / biosynthesis
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Plants, Medicinal / chemistry*
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Spleen / cytology
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Spleen / drug effects
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Tumor Necrosis Factor-alpha / antagonists & inhibitors
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Interleukin-2
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Lignans
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Tumor Necrosis Factor-alpha
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Nitric Oxide