Objective: To report a successful pregnancy in a woman with panhypopituitarism who received 3 months of pretreatment with growth hormone (GH) before ovulation induction. Prior attempts at ovulation induction had failed for this patient.
Design: Case report.
Setting: Department of Endocrinology.
Patient(s): A 32-year-old woman with panhypopituitarism and secondary infertility.
Intervention(s): GH (1 IU/day) alone for 3 months; during the next cycle, 1 IU/day of GH; 3 ampules of hMG per day during days 1-21; 1 ampule of hCG on day 21. GH was discontinued on day 35 when a pregnancy test was positive.
Main outcome measure(s): Pregnancy and delivery.
Results: Pregnancy and birth of a normal child after a single ovulation stimulation using GH and gonadotropins.
Conclusion(s): This case report suggests interest in a new protocol for follicular stimulation in women with hypopituitarism who are responding poorly to gonadotropin therapy.