Abstract
Synthesis and antiparasitic activity vs T. cruzi and L. donovani of a series of 9-thioaryl acridines are reported. A convenient correlation between molecular structure and biological activity is proposed. Results not only agree with the classical interactions of acridines with DNA but also suggest possible role of charge transfer complexes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acridines / chemical synthesis
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Acridines / pharmacology
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Animals
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Crystallography, X-Ray
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Magnetic Resonance Spectroscopy
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Quantitative Structure-Activity Relationship
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Trypanocidal Agents / chemical synthesis*
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Trypanocidal Agents / pharmacology
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Trypanosoma / drug effects*
Substances
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Acridines
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Trypanocidal Agents