[Morpho-functional changes of surfactant system in pulmonary tuberculosis]

Vestn Ross Akad Med Nauk. 2000:(12):31-6.
[Article in Russian]

Abstract

A complex study of different cellular and extracellular surfactant elements in the dynamics of the spontaneous course of generalized tuberculosis was made in 240 guinea-pigs and 77 patients with different forms of active pulmonary tuberculosis by using electron microscopy, biochemistry, and physical chemistry. A diagnostic scheme was proposed for life-time assessment of surfactant in bronchoalveolar lavage specimens. Three degrees of changes in surfactant were identified; 1) adaptive rearrangement of its elements developing in local surfactant damages; 2) significantly impaired type 2 alveolocyte production of surfactant, which affects its biochemical composition and capacity of forming characteristic structures; 3) common morphological, biochemical, surface-active signs of surfactant decompensation, profound metabolic disturbances, alveolar epithelial destruction with cleared alveolocytes found in the lavage.

Publication types

  • Comparative Study
  • English Abstract

MeSH terms

  • Animals
  • Biomarkers
  • Bronchoalveolar Lavage Fluid / chemistry
  • Bronchoalveolar Lavage Fluid / cytology
  • Disease Progression
  • Epithelium / metabolism
  • Epithelium / ultrastructure
  • Guinea Pigs
  • Humans
  • Pulmonary Alveoli / metabolism
  • Pulmonary Alveoli / ultrastructure*
  • Pulmonary Surfactants / metabolism*
  • Pulmonary Surfactants / ultrastructure
  • Tuberculosis, Pulmonary / metabolism*
  • Tuberculosis, Pulmonary / pathology

Substances

  • Biomarkers
  • Pulmonary Surfactants