Quantitative analysis of structure-activity relationship in the acridine series. Part 2: Antitumor 9-thiadiazolo-acridine derivatives

A Mrozek; J Karolak-Wojciechowska; P Amiel; J Barbe

Quantitative analysis of structure-activity relationship in the acridine series. Part 2: Antitumor 9-thiadiazolo-acridine derivatives

Acta Pol Pharm. 2000 Nov-Dec;57(6):425-30.

Authors

A Mrozek¹, J Karolak-Wojciechowska, P Amiel, J Barbe

Affiliation

¹ Technical University of Lódź, Poland.

PMID: 11243248

Abstract

Synthesis and activity, vs. leukaemia cells of new 9-thiadiazolo acridine derivatives are reported. In addition, electronic properties and molecular structure are correlated with biological activity of these molecules. Results are in agreement with the capability of drugs to intercalate into DNA.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acridines / pharmacology*
Animals
Antineoplastic Agents / pharmacology*
Leukemia L1210 / drug therapy
Leukemia L1210 / pathology
Mice
Quantitative Structure-Activity Relationship
Thiadiazoles / pharmacology*

Substances

Acridines
Antineoplastic Agents
Thiadiazoles