Quantitative analysis of structure-activity relationship in the acridine series. Part 2: Antitumor 9-thiadiazolo-acridine derivatives

Acta Pol Pharm. 2000 Nov-Dec;57(6):425-30.

Abstract

Synthesis and activity, vs. leukaemia cells of new 9-thiadiazolo acridine derivatives are reported. In addition, electronic properties and molecular structure are correlated with biological activity of these molecules. Results are in agreement with the capability of drugs to intercalate into DNA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acridines / pharmacology*
  • Animals
  • Antineoplastic Agents / pharmacology*
  • Leukemia L1210 / drug therapy
  • Leukemia L1210 / pathology
  • Mice
  • Quantitative Structure-Activity Relationship
  • Thiadiazoles / pharmacology*

Substances

  • Acridines
  • Antineoplastic Agents
  • Thiadiazoles