Abstract
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
MeSH terms
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Actins / metabolism
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Animals
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Caenorhabditis elegans Proteins*
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Cytoskeleton / metabolism
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Down-Regulation
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Embryonic Induction
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Helminth Proteins / metabolism
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Humans
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Mice
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Mice, Knockout
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Models, Molecular
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Oncogene Protein v-cbl
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Protein Structure, Tertiary
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Protein-Tyrosine Kinases / antagonists & inhibitors
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Protein-Tyrosine Kinases / metabolism*
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Proto-Oncogene Mas
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Proto-Oncogene Proteins / chemistry
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Proto-Oncogene Proteins / deficiency
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Proto-Oncogene Proteins / genetics
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Proto-Oncogene Proteins / metabolism*
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Proto-Oncogene Proteins c-cbl
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Receptor Protein-Tyrosine Kinases / antagonists & inhibitors
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Receptor Protein-Tyrosine Kinases / metabolism
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Retroviridae Proteins, Oncogenic / chemistry
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Retroviridae Proteins, Oncogenic / deficiency
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Retroviridae Proteins, Oncogenic / genetics
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Retroviridae Proteins, Oncogenic / metabolism
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Signal Transduction
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T-Lymphocytes / physiology
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Ubiquitin-Protein Ligases*
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Ubiquitins / metabolism
Substances
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Actins
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Caenorhabditis elegans Proteins
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Helminth Proteins
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MAS1 protein, human
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Oncogene Protein v-cbl
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Proto-Oncogene Mas
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Proto-Oncogene Proteins
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Retroviridae Proteins, Oncogenic
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Sli-1 protein, C elegans
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Ubiquitins
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Proto-Oncogene Proteins c-cbl
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Ubiquitin-Protein Ligases
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Protein-Tyrosine Kinases
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Receptor Protein-Tyrosine Kinases
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CBL protein, human
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Cbl protein, mouse