DNA repair: spot(light)s on chromatin

Curr Biol. 2001 Mar 20;11(6):R229-32. doi: 10.1016/s0960-9822(01)00112-9.

Abstract

Chromatin modifications regulate many nuclear processes. Recent studies on the phosphorylation of a histone 2A variant have revealed that this chromatin modification is a general and evolutionarily conserved cellular response to DNA double-strand breaks.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin / metabolism*
  • DNA Damage
  • DNA Nucleotidyltransferases / metabolism
  • DNA Repair*
  • Histones / metabolism*
  • Humans
  • Meiosis / physiology
  • Nuclear Proteins / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Recombination, Genetic
  • VDJ Recombinases

Substances

  • Chromatin
  • Histones
  • Nuclear Proteins
  • Phosphatidylinositol 3-Kinases
  • DNA Nucleotidyltransferases
  • VDJ Recombinases