This article briefly discusses and illustrates the major important neurodegenerative diseases of adulthood and neurometabolic (neurodegenerative in a broader sense) diseases of childhood and their gross neuropathology. Macroscopic views of the brain including the cerebellum and the brain stem and the spinal cord are given by external inspection as well as gross sections after brain cutting. Histologic details and photographs are supplied to explain and corroborate certain gross findings. This article attempts to correlate nosologic and neuropathologic features as the basis for interpreting neuroimaging data.