Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice

Brain Res. 2001 May 11;900(2):320-3. doi: 10.1016/s0006-8993(01)02293-4.

Abstract

We investigated the action of baclofen, an agonist for GABA(B) receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Adelta fibers. Baclofen (10 microM) reduced the amplitude of Adelta fiber-evoked glycine receptor-mediated IPSCs to 20.9+/-3.0% (n=13), and GABA(A) receptor-mediated IPSCs to 18.6+/-3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABA(B) receptor in spinal dorsal horn.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Baclofen / pharmacology*
  • Electric Conductivity
  • GABA Agonists / pharmacology*
  • In Vitro Techniques
  • Male
  • Neural Inhibition / physiology*
  • Neurons / physiology*
  • Patch-Clamp Techniques
  • Rats
  • Rats, Sprague-Dawley
  • Spinal Nerve Roots / drug effects
  • Spinal Nerve Roots / physiology*
  • Substantia Gelatinosa / cytology
  • Substantia Gelatinosa / physiology*
  • Synaptic Transmission / drug effects*

Substances

  • GABA Agonists
  • Baclofen