Mitochondrial DNA depletion, near-fatal metabolic acidosis, and liver failure in an HIV-infected child treated with combination antiretroviral therapy

J Pediatr. 2001 May;138(5):748-51. doi: 10.1067/mpd.2001.112653.

Abstract

A child with controlled human immunodeficiency virus infection presented with neurologic deterioration, lactic acidosis, and organic aciduria. Muscle biopsy revealed abnormal mitochondrial (mt) morphology, reduced mt enzyme activities, and mtDNA depletion. After adjustment of antiretroviral therapy to a regimen free of nucleoside analogs, marked improvement was seen in clinical status and mt abnormalities.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acidosis / etiology*
  • Antiretroviral Therapy, Highly Active / adverse effects*
  • Antiretroviral Therapy, Highly Active / methods
  • Biopsy
  • Child, Preschool
  • DNA, Mitochondrial / genetics
  • DNA, Mitochondrial / metabolism*
  • HIV Infections / drug therapy
  • Humans
  • Liver Failure / chemically induced*
  • Male
  • Muscle, Skeletal / pathology*
  • Spectrophotometry

Substances

  • DNA, Mitochondrial