[Primary uterine and vulvar Ewing's sarcoma/peripheral neuroectodermal tumors in children: two unusual locations]

T Lazure; I A Alsamad; S Meuric; D Orbach; M Fabre

[Primary uterine and vulvar Ewing's sarcoma/peripheral neuroectodermal tumors in children: two unusual locations]

Ann Pathol. 2001 Jun;21(3):263-6.

[Article in French]

Authors

T Lazure¹, I A Alsamad, S Meuric, D Orbach, M Fabre

Affiliation

¹ Service d'Anatomie et Cytologie Pathologiques, CHU de Bicêtre, 78, rue du Général Leclerc, 94275 Le Kremlin-Bicêtre Cedex.

PMID: 11468565

Abstract

Two genital cases of Ewing's sarcoma/peripheral neuroectodermal tumor in 14 and 15 year old teenagers are reported. They arose in uteri and vulva, as small round cell tumors with some rosette-like formations and intense membranous immunoreactivity for CD99. The EWS/FLI-1 transcript was present in the vulvar tumor. Under chemotherapy, uterine tumor outcome was fatal within 9 months. The vulvar lesion was treated by surgery and chemotherapy, without relapse after 7 months. Likewise to these 2 cases, the literature seems to indicate different prognosis for uterine and vulvar tumors.

Publication types

Case Reports

MeSH terms

12E7 Antigen
Adolescent
Antigens, CD / analysis
Antineoplastic Combined Chemotherapy Protocols / therapeutic use
Cell Adhesion Molecules / analysis
Fatal Outcome
Female
Humans
Magnetic Resonance Imaging
Neuroectodermal Tumors, Primitive, Peripheral / diagnosis*
Neuroectodermal Tumors, Primitive, Peripheral / pathology
Neuroectodermal Tumors, Primitive, Peripheral / therapy
Sarcoma, Ewing / diagnosis*
Sarcoma, Ewing / pathology
Sarcoma, Ewing / therapy
Uterine Neoplasms / diagnosis*
Uterine Neoplasms / drug therapy
Uterine Neoplasms / pathology
Vulva / surgery
Vulvar Neoplasms / diagnosis*
Vulvar Neoplasms / pathology
Vulvar Neoplasms / therapy

Substances

12E7 Antigen
Antigens, CD
CD99 protein, human
Cell Adhesion Molecules