Expression patterns of Slit and Robo family members during vertebrate limb development

Mech Dev. 2001 Aug;106(1-2):175-80. doi: 10.1016/s0925-4773(01)00430-0.

Abstract

We report the cloning and expression during limb development of the chicken Slit1, Slit2, and Slit3 ligands, and Robo1 and Robo2 receptor genes. We also compare the expression patterns of Robo1 and Robo2 in developing chick and mouse hindlimbs. These genes are expressed in regions of muscle development, chrondrogenesis, and axon guidance.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Chick Embryo
  • Extremities / embryology*
  • Gene Expression Profiling
  • Gene Expression*
  • Hindlimb / embryology
  • In Situ Hybridization
  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins / genetics*
  • Mesoderm / metabolism
  • Mice
  • Molecular Sequence Data
  • Nerve Tissue Proteins / genetics*
  • Rats
  • Receptors, Immunologic / genetics*
  • Roundabout Proteins
  • Slit Homolog 2 Protein

Substances

  • Intercellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • Receptors, Immunologic
  • Robo2 protein, mouse
  • Slit1 protein, mouse
  • Slit1 protein, rat
  • Slit3 protein, mouse
  • Slit3 protein, rat
  • Slit Homolog 2 Protein

Associated data

  • GENBANK/AF364044
  • GENBANK/AF364045
  • GENBANK/AF364046
  • GENBANK/AF364047
  • GENBANK/AF364048