Notch signaling in lymphocyte development

Curr Opin Genet Dev. 2001 Oct;11(5):554-60. doi: 10.1016/s0959-437x(00)00232-x.

Abstract

Signaling through Notch has been implicated in many cell-fate decisions during lymphocyte development. Recent studies have provided new clues--and raised new controversies--regarding the exact role that Notch signaling plays in the commitment of cells to the T-cell lineage. Progress has also been made in deducing the transcriptional program induced by Notch and the mechanism of oncogenic transformation by Notch in lymphocytes.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation*
  • Cell Lineage
  • Cell Transformation, Neoplastic
  • Gene Expression Regulation, Developmental
  • Hematopoietic Stem Cells / cytology
  • Hematopoietic Stem Cells / metabolism
  • Humans
  • Lymphocytes / cytology*
  • Lymphocytes / metabolism*
  • Membrane Proteins / metabolism*
  • Receptors, Notch
  • Signal Transduction*
  • T-Lymphocytes / cytology
  • T-Lymphocytes / metabolism
  • Thymus Gland / cytology
  • Thymus Gland / metabolism
  • Transcription, Genetic

Substances

  • Membrane Proteins
  • Receptors, Notch