Genetic protection from the inflammatory disease type 1 diabetes in humans and animal models

Immunity. 2001 Sep;15(3):387-95. doi: 10.1016/s1074-7613(01)00202-3.

Abstract

Populations of humans and mice contain alleles at many loci that protect from immune-mediated diseases. Identification of these alleles, some which are likely to function in immune recognition, tolerance, and regulation, will facilitate the development of diagnostics as well as therapeutics that alter disease progression.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Alleles
  • Animals
  • Chromosome Mapping
  • Diabetes Mellitus, Type 1 / genetics*
  • Diabetes Mellitus, Type 1 / therapy
  • Disease Models, Animal
  • Genes, MHC Class II
  • HLA-DQ Antigens / genetics
  • Humans
  • Insulin
  • Multigene Family
  • Proinsulin / genetics
  • Protein Precursors / genetics

Substances

  • HLA-DQ Antigens
  • Insulin
  • Protein Precursors
  • preproinsulin
  • Proinsulin