The ins and outs of GroEL-mediated protein folding

Mol Cell. 2001 Oct;8(4):730-2. doi: 10.1016/s1097-2765(01)00359-8.

Abstract

Two papers recently published in Cell investigate the role of protein encapsulation by GroEL in assisting folding. The first shows how encapsulation can "smooth" the folding landscape, accelerating folding of some proteins. The second defines a confinement-independent pathway, which allows GroEL to assist folding of substrates too large to be encapsulated.

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Catalytic Domain
  • Chaperonin 10 / metabolism
  • Chaperonin 60 / chemistry
  • Chaperonin 60 / metabolism*
  • Escherichia coli / enzymology
  • Escherichia coli / metabolism
  • Ligands
  • Models, Biological
  • Protein Conformation
  • Protein Folding*
  • Ribulose-Bisphosphate Carboxylase

Substances

  • Chaperonin 10
  • Chaperonin 60
  • Ligands
  • Adenosine Triphosphate
  • Ribulose-Bisphosphate Carboxylase