Viral-based gene transfer to the mammalian CNS for functional genomic studies

C G Janson; S W McPhee; P Leone; A Freese; M J During

doi:10.1016/s0166-2236(00)01954-8

Viral-based gene transfer to the mammalian CNS for functional genomic studies

Trends Neurosci. 2001 Dec;24(12):706-12. doi: 10.1016/s0166-2236(00)01954-8.

Authors

C G Janson¹, S W McPhee, P Leone, A Freese, M J During

Affiliation

¹ CNG Gene Therapy Center, Jefferson Medical College, 1025 Walnut Street, Suite 511, Philadelphia, PA 19107, USA. cjanson@hotmail.com

PMID: 11718875
DOI: 10.1016/s0166-2236(00)01954-8

Abstract

A fundamental problem in neuroscience has been the creation of suitable in vivo model systems to study basic neurological phenomena and pathology of the central nervous system (CNS). Somatic cell genetic engineering with viral vectors provides a versatile tool to model normal brain physiology and a variety of neurological diseases.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Animals
Brain / physiology*
Brain Diseases / physiopathology
Gene Transfer Techniques*
Genetic Vectors
Mammals
Viruses / genetics*