Mechanisms of epileptogenicity in focal malformations caused by abnormal cortical development

Zhong Ying; Imad M Najm

doi:10.1016/s1042-3680(02)80004-3

Mechanisms of epileptogenicity in focal malformations caused by abnormal cortical development

Neurosurg Clin N Am. 2002 Jan;13(1):27-33, vii. doi: 10.1016/s1042-3680(02)80004-3.

Authors

Zhong Ying¹, Imad M Najm

Affiliation

¹ Section of Epilepsy, Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. yingz@ccf.org

PMID: 11754314
DOI: 10.1016/s1042-3680(02)80004-3

Abstract

In this article, the authors review the cellular mechanisms of epileptogenicity in malformations caused by abnormalities of cortical development as related to neuronal excitation, reduced inhibition, disorganized synaptic connections, and glial function (or dysfunction).

MeSH terms

Animals
Cerebral Cortex / abnormalities*
Cerebral Cortex / pathology
Disease Models, Animal
Epilepsies, Partial / congenital*
Epilepsies, Partial / genetics
Epilepsies, Partial / pathology
Gene Expression Regulation / physiology
Humans
Receptors, Neurotransmitter / genetics

Substances

Receptors, Neurotransmitter