Hedgehog patterns midbrain ARChitecture

Trends Neurosci. 2002 Jan;25(1):10-1. doi: 10.1016/s0166-2236(00)01982-2.

Abstract

Recent work from Agarwala et al. has uncovered exquisite ventral patterning in the mesencephalon. Using electroporation in chicks, they show that ectopic expression of Sonic Hedgehog (Shh) in dorsal mesencephalon can recapitulate this patterning in its entirety. These results are discussed in the context of the purported role of Shh as a morphogen.

Publication types

  • Review

MeSH terms

  • Animals
  • Body Patterning / physiology*
  • Bone Morphogenetic Proteins / metabolism
  • Cell Differentiation / physiology*
  • Chick Embryo
  • Embryonic Induction / physiology
  • Hedgehog Proteins
  • Humans
  • Mesencephalon / cytology
  • Mesencephalon / embryology*
  • Mesencephalon / metabolism
  • Neurons / cytology
  • Neurons / metabolism*
  • Notochord / metabolism
  • Trans-Activators / metabolism*

Substances

  • Bone Morphogenetic Proteins
  • Hedgehog Proteins
  • SHH protein, human
  • Trans-Activators