Abstract
This study shows that vascular smooth muscle cells express significantly higher levels of gamma interferon-inducible indoleamine 2,3-dioxygenase (IDO) activity than endothelium or mononuclear cells. Since IDO activity is linked to persistent Chlamydophila pneumoniae infection, our results suggest that smooth muscle cells may be an important reservoir of that organism in atherosclerosis.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Arteriosclerosis / enzymology*
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CD4-Positive T-Lymphocytes / cytology
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CD4-Positive T-Lymphocytes / drug effects
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CD4-Positive T-Lymphocytes / enzymology
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Cells, Cultured
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Chlamydophila Infections / enzymology*
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Chlamydophila pneumoniae / physiology*
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Endothelium, Vascular / cytology
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Endothelium, Vascular / enzymology
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Humans
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Interferon-gamma / pharmacology*
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Kynurenine / analogs & derivatives*
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Kynurenine / metabolism
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Leukocytes, Mononuclear / cytology
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Leukocytes, Mononuclear / drug effects
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Leukocytes, Mononuclear / enzymology
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Muscle, Smooth, Vascular / cytology
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Muscle, Smooth, Vascular / enzymology*
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Substrate Specificity
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Tryptophan / metabolism
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Tryptophan Oxygenase / metabolism*
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Tumor Necrosis Factor-alpha / pharmacology*
Substances
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Indoleamine-Pyrrole 2,3,-Dioxygenase
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Tumor Necrosis Factor-alpha
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N'-formylkynurenine
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Kynurenine
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Interferon-gamma
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Tryptophan
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Tryptophan Oxygenase