Risk factors for subsequent cervicovaginal human papillomavirus (HPV) infection and the protective role of antibodies to HPV-16 virus-like particles

J Infect Dis. 2002 Sep 15;186(6):737-42. doi: 10.1086/342972. Epub 2002 Aug 28.

Abstract

A high incidence of initial infection with human papillomavirus (HPV) was previously reported in a cohort of 608 women monitored at 6-month intervals for 3 years. Risk factors for subsequent infections with different HPV types and whether antibodies against HPV-16 virus-like particles (VLPs) protected against these infections were examined. Subsequent infections with HPV are very common. Seventy percent of women acquired a different HPV type within 24 months of the initial infection. Risk factors included being nonwhite, having an increased number of male sex partners, and having had a new male sex partner. Use of oral contraceptive pills was protective. A sustained high level of IgG antibody to HPV-16 VLPs was associated with reduced risk for subsequent infection with HPV-16 and its genetically related types (i.e., HPV-31, -33, -35, -52, and -58).

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Viral / blood
  • Cervix Uteri / virology*
  • Contraceptives, Oral
  • Ethnicity
  • Female
  • Genes, Viral
  • Humans
  • Male
  • Papillomaviridae / genetics
  • Papillomaviridae / immunology*
  • Papillomaviridae / isolation & purification
  • Papillomavirus Infections / etiology*
  • Papillomavirus Infections / immunology*
  • Papillomavirus Infections / virology
  • Risk Factors
  • Sexual Behavior / physiology
  • Sexual Partners
  • Tumor Virus Infections / etiology*
  • Tumor Virus Infections / immunology*
  • Tumor Virus Infections / virology
  • Vagina / virology*

Substances

  • Antibodies, Viral
  • Contraceptives, Oral