Abstract
Only a few patients with Parkinson's disease and levodopa dependency or abuse have been reported. We present a 35-year-old patient with young-onset Parkinson's disease who developed motor complications, levodopa dependency, and drug-induced psychosis after primary treatment with levodopa. Diagnostic criteria and treatment guidelines for this neuropsychiatric disorder are presented as well as a tentative neurobiological answer to the question of why levodopa dependency is observed only in a minority of patients with Parkinson's disease.
Publication types
-
Case Reports
-
English Abstract
MeSH terms
-
Adult
-
Antiparkinson Agents* / administration & dosage
-
Antiparkinson Agents* / adverse effects
-
Combined Modality Therapy
-
Diagnosis, Differential
-
Dose-Response Relationship, Drug
-
Humans
-
Levodopa* / administration & dosage
-
Levodopa* / adverse effects
-
Limbic System / drug effects
-
Male
-
Mental Status Schedule
-
Mesencephalon / drug effects
-
Neurologic Examination / drug effects
-
Parkinson Disease / diagnosis
-
Parkinson Disease / drug therapy*
-
Parkinson Disease / psychology
-
Parkinson Disease / rehabilitation
-
Patient Care Team
-
Psychoses, Substance-Induced / diagnosis*
-
Psychoses, Substance-Induced / psychology
-
Psychoses, Substance-Induced / rehabilitation
-
Receptors, Dopamine / drug effects
-
Substance-Related Disorders / diagnosis*
-
Substance-Related Disorders / psychology
-
Substance-Related Disorders / rehabilitation
Substances
-
Antiparkinson Agents
-
Receptors, Dopamine
-
Levodopa