Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians

Igal Ifergan; Nicole F Bernard; Julie Bruneau; Michel Alary; Christos M Tsoukas; Michel Roger

doi:10.1097/00002030-200211220-00017

Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians

AIDS. 2002 Nov 22;16(17):2340-2. doi: 10.1097/00002030-200211220-00017.

Authors

Igal Ifergan¹, Nicole F Bernard, Julie Bruneau, Michel Alary, Christos M Tsoukas, Michel Roger

Affiliation

¹ Laboratoire d'Immunogénétique, Centre de Recherche du Centre Hospitalier, l'Université de Montréal, Montréal, Canada.

PMID: 12441809
DOI: 10.1097/00002030-200211220-00017

Abstract

Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Gene Frequency*
Genes, MDR*
Genetic Predisposition to Disease*
HIV Infections / genetics*
HIV-1*
Humans
Polymorphism, Genetic
Prospective Studies