Emergence of drug-resistant HIV-1 variants in patients undergoing structured treatment interruptions

AIDS. 2002 Nov 22;16(17):2342-4. doi: 10.1097/00002030-200211220-00018.

Abstract

We report the emergence of drug-resistant viral mutations in chronically HIV-infected individual undergoing structured treatment interruptions (STI). THe protease mutations K101E and K103N were detected at the end of the second or third STI. We concluded that the repeated abrupt termination and resumption of certain antiretroviral drug regimens during STI therapy may lead to the development of drug resistance in chronically HIV-infected individuals.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Anti-HIV Agents / administration & dosage*
  • Drug Administration Schedule
  • Drug Resistance, Viral / genetics*
  • Drug Therapy, Combination
  • HIV Infections / drug therapy*
  • HIV Infections / virology
  • HIV-1 / drug effects*
  • HIV-1 / genetics
  • Humans
  • Mutation
  • RNA, Viral / genetics

Substances

  • Anti-HIV Agents
  • RNA, Viral