Abstract
The protective effect of an early full-term pregnancy is a well established phenomenon; in contrast, the molecular and cell-specific mechanisms that govern parity-specific changes in the mammary gland have not been well described. Recent studies signify a dramatic advance in our understanding of this phenomenon, and indicate a 'cell fate' model for parity-related changes that lead to protection against breast cancer.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Female
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Gene Expression
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Mammary Glands, Animal / metabolism
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Mammary Glands, Animal / pathology*
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Mammary Neoplasms, Animal / etiology
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Mammary Neoplasms, Animal / genetics
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Mice
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Parity
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Pregnancy
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Pregnancy Complications*
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Rats
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Tumor Suppressor Protein p53 / genetics
Substances
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Tumor Suppressor Protein p53