Synthesis and antibacterial activity of oxazolidinone containing sulphonyl group

Bioorg Med Chem Lett. 2003 Jul 21;13(14):2311-3. doi: 10.1016/s0960-894x(03)00430-x.

Abstract

A series of oxazolidinone derivatives carrying sulphonyl group was synthesized and their antibacterial activity was evaluated in vitro. Many of such compounds demonstrated potent antibacterial activity. The activity of a novel compound (YC-20) was 2-4-fold more potent than that of linezolid.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / pharmacology
  • Anti-Infective Agents / chemical synthesis*
  • Anti-Infective Agents / pharmacology*
  • Bacteria / drug effects*
  • Chemical Phenomena
  • Chemistry, Physical
  • Gram-Positive Bacteria / drug effects
  • Linezolid
  • Microbial Sensitivity Tests
  • Oxazoles / chemical synthesis*
  • Oxazoles / pharmacology*
  • Oxazolidinones / pharmacology
  • Structure-Activity Relationship
  • Sulfonamides / chemical synthesis*
  • Sulfonamides / pharmacology*

Substances

  • Acetamides
  • Anti-Infective Agents
  • Oxazoles
  • Oxazolidinones
  • Sulfonamides
  • Linezolid