Human papillomavirus-associated lesions of the vagina and cervix. Treatment with a laser and topical 5-fluorouracil

J Reprod Med. 1992 May;37(5):453-6.

Abstract

Twenty women with cervical and vaginal human papillomavirus-associated lesions were treated with CO2 laser ablation followed by eight weekly applications of 5-fluorouracil. Viral subtyping in a majority of patients and histology were obtained before and after treatment. After treatment 88% (15 of 17) had normal vaginal biopsies, and 59% (10 of 17) had normal cervical biopsies. There were no treatment failures with subtype 6/11 infection of the cervix or vagina. All the failures were with viral subtypes 16/18 and 31/35/51. The protocol was effective in treating patients with cervical and vaginal human papillomavirus-associated lesions.

MeSH terms

  • Administration, Topical
  • Biopsy
  • Clinical Protocols / standards
  • Combined Modality Therapy
  • DNA
  • Female
  • Fluorouracil / administration & dosage
  • Fluorouracil / therapeutic use*
  • Follow-Up Studies
  • Humans
  • Laser Therapy / methods
  • Laser Therapy / standards*
  • Nucleic Acid Hybridization
  • Papillomaviridae*
  • Treatment Outcome
  • Tumor Virus Infections / diagnosis
  • Tumor Virus Infections / pathology
  • Tumor Virus Infections / therapy*
  • Uterine Cervical Diseases / diagnosis
  • Uterine Cervical Diseases / pathology
  • Uterine Cervical Diseases / therapy*
  • Vaginal Diseases / diagnosis
  • Vaginal Diseases / pathology
  • Vaginal Diseases / therapy*

Substances

  • DNA
  • Fluorouracil