Exclusion of linkage between hypokalemic periodic paralysis (HOKPP) and three candidate loci

Genomics. 1992 Oct;14(2):493-4. doi: 10.1016/s0888-7543(05)80249-6.

Abstract

Hypokalemic periodic paralysis (HOKPP) is an autosomal dominant neuromuscular disorder characterized by flaccid paralysis accompanied by lowered serum potassium levels. We have tested polymorphic markers linked to the adult skeletal muscle sodium channel (SCN4A) locus at 17q23-q25, the T-cell receptor beta (TCRB) locus at 7q35, and the H-Ras cellular proton-cogene locus (HRAS) at 11p15.5 for linkage with the affected phenotype in a single multigenerational pedigree. No evidence for genetic linkage to HOKPP was found at any of the candidate loci.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human, Pair 17
  • Chromosomes, Human, Pair 7
  • Genetic Linkage*
  • Humans
  • Hypokalemia / genetics*
  • Muscles / metabolism
  • Paralyses, Familial Periodic / genetics*
  • Phenotype
  • Polymorphism, Genetic
  • Receptors, Antigen, T-Cell, alpha-beta / genetics
  • Sodium Channels / genetics

Substances

  • Receptors, Antigen, T-Cell, alpha-beta
  • Sodium Channels