Synthesis, characterization and biodistribution of the cationic technetium(II) 1,10-phenanthroline chelate

K Schwochau; K H Linse; Z F Su

doi:10.1016/0883-2889(92)90047-i

Synthesis, characterization and biodistribution of the cationic technetium(II) 1,10-phenanthroline chelate

Int J Rad Appl Instrum A. 1992 Sep;43(9):1079-82. doi: 10.1016/0883-2889(92)90047-i.

Authors

K Schwochau¹, K H Linse, Z F Su

Affiliation

¹ Institut für Chemie 1 (Nuklearchemie), Forschungszentrum Jülich GmbH (KFA), Germany.

PMID: 1330986
DOI: 10.1016/0883-2889(92)90047-i

Abstract

[99Tc(phen)3]Cl2 was synthesized by reduction of pertechnetate with sodium borohydride in the presence of an excess of 1,10-phenanthroline and characterized by FAB mass spectrometry, magnetic susceptibility measurements, and i.r./vis/u.v. spectrophotometry. For biodistribution evaluation in mice [99mTc(phen)3]Cl2 could be obtained in a radiochemical purity of 92.5% using a similar procedure. The rather hydrophilic chelate was predominantly excreted by the kidneys. Its low blood retention resulted in a heart/blood activity ratio of 4.2 at 100 min post-injection.

MeSH terms

Animals
Mice
Organotechnetium Compounds / chemical synthesis*
Organotechnetium Compounds / pharmacokinetics
Phenanthrolines / chemical synthesis*
Phenanthrolines / pharmacokinetics
Spectrometry, Mass, Fast Atom Bombardment
Tissue Distribution

Substances

Organotechnetium Compounds
Phenanthrolines
technetium Tc 99m 1,10-phenanthroline