The contribution of the different binding sites of the N-methyl-D-aspartate (NMDA) receptor to the expression of behavior

J Neural Transm Gen Sect. 1992;87(1):23-35. doi: 10.1007/BF01253108.

Abstract

The effects of competitive (CGP 37849 and CGP 39551) and non-competitive (dizocilpine) N-methyl-D-aspartate (NMDA) antagonists were tested in three animal models (catalepsy, sniffing, locomotion) and, in addition, the modulation of these effects by an agonist of the strychnine-insensitive glycine binding site was investigated. Both competitive and non-competitive NMDA antagonists reduced neuroleptic-induced catalepsy. Weak sniffing was induced by the competitive antagonist but strong sniffing by the non-competitive NMDA antagonist. Due to muscle relaxation the competitive antagonist reduced locomotion, in contrast to stimulation of locomotor activity induced by the non-competitive NMDA antagonist. The glycine agonist (D-cycloserine) potentiated the effects of the non-competitive but antagonized those of the competitive NMDA antagonist.

MeSH terms

  • 2-Amino-5-phosphonovalerate / analogs & derivatives
  • 2-Amino-5-phosphonovalerate / pharmacology
  • Animals
  • Behavior, Animal / physiology*
  • Binding Sites / drug effects
  • Catalepsy / chemically induced
  • Catalepsy / physiopathology
  • Cycloserine / pharmacology
  • Dizocilpine Maleate / pharmacology
  • Haloperidol / pharmacology
  • Male
  • Motor Activity / drug effects
  • Rats
  • Rats, Inbred Strains
  • Receptors, N-Methyl-D-Aspartate / antagonists & inhibitors
  • Receptors, N-Methyl-D-Aspartate / drug effects
  • Receptors, N-Methyl-D-Aspartate / physiology*

Substances

  • Receptors, N-Methyl-D-Aspartate
  • CGP 39551
  • 2-amino-4-methyl-5-phosphono-3-pentenoic acid
  • Dizocilpine Maleate
  • 2-Amino-5-phosphonovalerate
  • Cycloserine
  • Haloperidol