Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1

Y Shen; E Baker; D F Callen; G R Sutherland; T A Willson; S Rakar; N M Gough

doi:10.1159/000133401

Localization of the human GM-CSF receptor beta chain gene (CSF2RB) to chromosome 22q12.2-->q13.1

Cytogenet Cell Genet. 1992;61(3):175-7. doi: 10.1159/000133401.

Authors

Y Shen¹, E Baker, D F Callen, G R Sutherland, T A Willson, S Rakar, N M Gough

Affiliation

¹ Department of Cytogenetics and Molecular Genetics, Adelaide Children's Hospital, North Adelaide, South Australia.

PMID: 1424804
DOI: 10.1159/000133401

Abstract

The gene for the beta-chain of the human GM-CSF receptor (CSF2RB) has been mapped to chromosome 22 by PCR analysis of a series of human x rodent somatic cell hybrids. In situ hybridization to normal human chromosomes and two translocations involving chromosome 22 and the chromosome expressing the rare fragile site FRA22A place the gene in the region 22q12.2-->q13.1, proximal to the fragile site.

MeSH terms

Chromosomes, Human, Pair 22*
Humans
Hybrid Cells
In Situ Hybridization, Fluorescence
Oligonucleotide Probes / genetics
Polymerase Chain Reaction
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor / genetics*
Translocation, Genetic / genetics*

Substances

Oligonucleotide Probes
Receptors, Granulocyte-Macrophage Colony-Stimulating Factor