Partial molar volumes of mRNA 5' cap analogues

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):1553-6. doi: 10.1081/NCN-120023032.

Abstract

Partial molar volumes in aqueous solution of eleven selected 7-methylguanine cap-analogues and their guanine counterparts were determined by means of density measurements. Hydrophobicity of the investigated compounds regarding their structural features was analysed within the framework of the solute-solvent interaction model, based on the relative density of the molecular solvation shell.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Guanine* / analogs & derivatives*
  • Guanosine Monophosphate / analogs & derivatives*
  • Guanosine Monophosphate / chemistry*
  • Nucleic Acid Conformation
  • RNA Caps / chemistry*
  • Structure-Activity Relationship

Substances

  • RNA Caps
  • Guanine
  • 7-methylguanine
  • Guanosine Monophosphate