Abstract
Cytokines modify neuronal function. Dysfunction in vital centers is reported in sudden infant death syndrome (SIDS). The authors detected high neuronal interleukin (IL)-1beta immunoreactivity in the arcuate and dorsal vagal nuclei in SIDS. This IL-1 overexpression might contribute to molecular interactions in brainstem neurovegetative centers, causing disturbed homeostatic control of cardiorespiratory and arousal responses, possibly leading to SIDS.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Arcuate Nucleus of Hypothalamus / pathology
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Brain / pathology*
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Brain Chemistry*
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Brain Stem / pathology
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Cytokines / analysis*
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Female
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Humans
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Immunohistochemistry
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Infant
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Infant, Newborn
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Interleukin-1 / analysis*
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Interleukin-6 / analysis
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Male
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Neurons / pathology
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Organ Size
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Sudden Infant Death / etiology
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Sudden Infant Death / pathology*
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Syndrome
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Tumor Necrosis Factor-alpha / analysis
Substances
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Cytokines
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Interleukin-1
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Interleukin-6
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Tumor Necrosis Factor-alpha