[Movement disorders in childhood: classification and genetic update]

Arch Pediatr. 2003 Nov;10(11):994-1002. doi: 10.1016/j.arcped.2003.07.003.
[Article in French]

Abstract

Abnormal movements are not unusual in childhood. Recent genetic progresses provide a new approach of childhood movement disorders. Several loci have been identified in paroxysmal dyskinesia, or in Gilles de la Tourette syndrome. A gene has been cloned in Hallervorden-Spatz syndrome, and a gene has recently been implicated in benign hereditary chorea. Considerable advances concern the genetic of dystonic syndromes: several chromosomal localizations have been identified, and several genes have been cloned. Genetic advances allow nosographic reclassification of some entities and offer new molecular tools for a more appropriate diagnosis. The increasing wealth of genetic knowledge will provide further insight in the understanding of abnormal movement disorders in childhood.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Child
  • Genetic Predisposition to Disease*
  • Genetic Testing
  • Humans
  • Movement Disorders / classification*
  • Movement Disorders / genetics*