Interstitial radiosurgery in the treatment of gelastic epilepsy due to hypothalamic hamartomas

Neurology. 2004 Feb 24;62(4):644-7. doi: 10.1212/01.wnl.0000110194.77056.65.

Abstract

The authors evaluated a new stereotactic radiosurgical approach in seven patients with gelastic epilepsy due to hypothalamic hamartomas. Stereotactic implantation of 125I-seeds into the hamartoma was feasible in six patients. At follow-up at least 1 year after interstitial radiotherapy, two patients had become seizure-free within 2 months, and two others had only persisting auras. There were no major perioperative or postoperative side effects.

Publication types

  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Brachytherapy / methods*
  • Child
  • Drug Implants
  • Drug Resistance
  • Epilepsies, Partial / etiology
  • Epilepsies, Partial / radiotherapy
  • Epilepsies, Partial / surgery*
  • Female
  • Follow-Up Studies
  • Hamartoma / complications
  • Hamartoma / radiotherapy
  • Hamartoma / surgery*
  • Humans
  • Hypothalamic Diseases / complications
  • Hypothalamic Diseases / radiotherapy
  • Hypothalamic Diseases / surgery*
  • Iodine Radioisotopes / administration & dosage
  • Iodine Radioisotopes / therapeutic use*
  • Male
  • Radiosurgery* / methods
  • Treatment Outcome

Substances

  • Drug Implants
  • Iodine Radioisotopes