DNA variants in the human RAB3A gene are not associated with autism

Genes Brain Behav. 2004 Apr;3(2):123-4. doi: 10.1111/j.1601-183x.2003.00058.x.

Abstract

Mutation screening of the RAB3A gene in 47 individuals with autism provided no evidence that DNA variants in this gene are associated with autism. Since Rab3a constitutive knockout mice react to novel stimuli with hyperactivity, a further search for association of RAB3A DNA variants with other neurobehavioral disorders such as attention deficit/hyperactivity disorder appears justified.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autistic Disorder / genetics*
  • Behavior, Animal / physiology
  • Case-Control Studies
  • Chromosomes, Human, Pair 19*
  • Exploratory Behavior / physiology
  • Humans
  • Mice
  • Polymorphism, Genetic*
  • rab3A GTP-Binding Protein / genetics*

Substances

  • rab3A GTP-Binding Protein