Healing of severe ulcerative necrobiosis lipoidica with cyclosporin

Australas J Dermatol. 2004 May;45(2):119-22. doi: 10.1111/j.1440-0960.2004.00059.x.

Abstract

A 55-year-old woman with severe, chronic, treatment-resistant ulcerating necrobiosis lipoidica of the shins was commenced on oral cyclosporin at a dose of 2.5 mg/kg/day. Improvement started within 1 week of commencing treatment, and the lesions healed completely over 8 months. Further ulceration occurred 3 months after discontinuing cyclosporin, with improvement on reintroduction of cyclosporin. There have been four previous case reports of healing of treatment-resistant ulcerating necrobiosis lipoidica with cyclosporin.

Publication types

  • Case Reports

MeSH terms

  • Cyclosporine / therapeutic use*
  • Dermatologic Agents / therapeutic use*
  • Female
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents / therapeutic use*
  • Middle Aged
  • Necrobiosis Lipoidica / drug therapy*
  • Recurrence
  • Skin Ulcer / drug therapy
  • Wound Healing

Substances

  • Dermatologic Agents
  • Immunosuppressive Agents
  • Cyclosporine