A new 2-carbamoyl pteridine that inhibits mycobacterial FtsZ

Bioorg Med Chem Lett. 2004 Jun 21;14(12):3161-4. doi: 10.1016/j.bmcl.2004.04.012.

Abstract

The preparation of a new 2-carbamoyl pteridine, its activity data against FtsZ from M. tuberculosis (Mtb), and in vitro antibacterial data against Mtb strain H37Ra are presented.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antitubercular Agents / chemistry*
  • Antitubercular Agents / pharmacology*
  • Bacterial Proteins / antagonists & inhibitors*
  • Bacterial Proteins / physiology
  • Cytoskeletal Proteins / antagonists & inhibitors*
  • Cytoskeletal Proteins / physiology
  • Mycobacterium tuberculosis / drug effects*
  • Mycobacterium tuberculosis / growth & development*
  • Pteridines / chemistry*
  • Pteridines / pharmacology*

Substances

  • Antitubercular Agents
  • Bacterial Proteins
  • Cytoskeletal Proteins
  • FtsZ protein, Bacteria
  • Pteridines