The alpha-specific cell identity factor Sxi1alpha is not required for virulence of Cryptococcus neoformans

Infect Immun. 2004 Jun;72(6):3643-5. doi: 10.1128/IAI.72.6.3643-3645.2004.

Abstract

Cryptococcus neoformans is a human fungal pathogen that has two mating types (a and alpha). Experiments have shown that in some backgrounds alpha strains are more virulent than a strains. Our studies reveal that the only known alpha-specific factor, SXI1alpha, is not necessary for virulence.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cryptococcus neoformans / genetics
  • Cryptococcus neoformans / pathogenicity*
  • Gene Deletion
  • Gene Expression Regulation, Fungal*
  • Genes, Fungal / genetics*
  • Humans
  • Meningitis, Cryptococcal / microbiology
  • Meningitis, Cryptococcal / physiopathology
  • Mice
  • Mice, Inbred DBA
  • Serotyping
  • Virulence